:root {
  --navy: #071d52;
  --footer: #0d2764;
  --purple: #78207f;
  --blue: #1783ba;
  --ink: #101827;
  --muted: #f2f2f2;
  --line: #d9dce3;
  --content: 1280px;
  --font-sans: "Noto Sans JP", "Yu Gothic", YuGothic, sans-serif;
  --font-serif: "Noto Serif JP", "Yu Mincho", YuMincho, serif;
}

* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
  background: var(--footer);
}

.fade-ready .js-fade-up {
  opacity: 0;
  transform: translateY(16px);
  transition:
    opacity 0.6s cubic-bezier(.22, .61, .36, 1),
    transform 0.6s cubic-bezier(.22, .61, .36, 1);
  transition-delay: var(--fade-delay, 0s);
  will-change: opacity, transform;
}

.fade-ready .js-fade-up.is-visible {
  opacity: 1;
  transform: translateY(0);
}

.fade-delay-1 { --fade-delay: .08s; }
.fade-delay-2 { --fade-delay: .18s; }
.fade-delay-3 { --fade-delay: .3s; }

@media (prefers-reduced-motion: reduce) {
  .fade-ready .js-fade-up {
    opacity: 1;
    transform: none;
    transition: none;
  }
}

body {
  margin: 0;
  color: var(--ink);
  background: #fff;
  font-family: var(--font-sans);
  font-size: 18px;
  font-weight: 400;
  line-height: 1.8;
  -webkit-font-smoothing: antialiased;
}

a {
  color: inherit;
}

h1,
h2 {
  font-family: var(--font-serif);
  font-weight: 600;
}

button {
  font-family: var(--font-sans);
}

.site-header {
  background: rgba(255, 255, 255, 0.98);
}

.header-main,
.global-nav ul,
.section-inner,
.footer-inner {
  width: min(calc(100% - 80px), var(--content));
  margin-inline: auto;
}

.header-main {
  min-height: 100px;
  position: relative;
  display: flex;
  align-items: center;
  gap: 42px;
  padding: 10px 116px 18px 0;
}

.brand {
  display: flex;
  align-items: center;
  gap: 15px;
  text-decoration: none;
  white-space: nowrap;
}

.brand-mark {
  width: 40px;
  height: auto;
  display: block;
  flex: 0 0 auto;
  object-fit: contain;
}

.brand-name {
  color: #101c44;
  font-family: var(--font-serif);
  font-size: 30px;
  font-weight: 600;
  line-height: 1.15;
  letter-spacing: -.025em;
}

.site-header .brand-name {
  font-family: Georgia, "Times New Roman", serif;
}

.institute {
  min-width: 0;
  color: var(--navy);
  font-size: 19px;
  font-weight: 600;
  line-height: 1.45;
  text-align: left;
}

.language-switch {
  position: absolute;
  top: 20px;
  right: 0;
  display: inline-flex;
  align-items: center;
  gap: 7px;
  color: var(--navy);
  font-size: 17px;
  line-height: 1;
  letter-spacing: .04em;
  text-decoration: none;
}

.language-switch::before,
.global-nav .nav-language a::before {
  content: "";
  width: 18px;
  height: 18px;
  display: block;
  flex: 0 0 auto;
  background: currentColor;
  -webkit-mask: url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 24 24'%3E%3Ccircle cx='12' cy='12' r='9.5' fill='none' stroke='black' stroke-width='1.8'/%3E%3Cpath d='M2.8 12h18.4M12 2.5c3 2.7 4.5 5.9 4.5 9.5S15 18.8 12 21.5M12 2.5C9 5.2 7.5 8.4 7.5 12S9 18.8 12 21.5M4.6 6.9c2.1 1.2 4.6 1.8 7.4 1.8s5.3-.6 7.4-1.8M4.6 17.1c2.1-1.2 4.6-1.8 7.4-1.8s5.3.6 7.4 1.8' fill='none' stroke='black' stroke-width='1.5' stroke-linecap='round'/%3E%3C/svg%3E") center / contain no-repeat;
  mask: url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 24 24'%3E%3Ccircle cx='12' cy='12' r='9.5' fill='none' stroke='black' stroke-width='1.8'/%3E%3Cpath d='M2.8 12h18.4M12 2.5c3 2.7 4.5 5.9 4.5 9.5S15 18.8 12 21.5M12 2.5C9 5.2 7.5 8.4 7.5 12S9 18.8 12 21.5M4.6 6.9c2.1 1.2 4.6 1.8 7.4 1.8s5.3-.6 7.4-1.8M4.6 17.1c2.1-1.2 4.6-1.8 7.4-1.8s5.3.6 7.4 1.8' fill='none' stroke='black' stroke-width='1.5' stroke-linecap='round'/%3E%3C/svg%3E") center / contain no-repeat;
}

.language-switch:hover {
  color: var(--blue);
  text-decoration: underline;
  text-underline-offset: 4px;
}

.global-nav {
  position: relative;
  font-size: 0;
  background: rgba(255, 255, 255, .97);
  border-bottom: 1px solid #9aa1ae;
}

.global-nav ul {
  padding: 0;
  display: flex;
  align-items: center;
  justify-content: space-between;
  list-style: none;
}

.global-nav li {
  flex: 1;
  text-align: center;
  border-right: 1px solid #d9d9d9;
}

.global-nav li:last-child {
  border-right: 0;
}

.global-nav li:nth-last-child(2) {
  border-right: 0;
}

.global-nav .nav-language {
  display: none;
}

.global-nav a {
  display: block;
  padding: 1px 14px;
  color: #101a42;
  font-family: var(--font-sans);
  font-size: 17px;
  font-weight: 500;
  line-height: 1.2;
  text-decoration: none;
  transition: color 0.2s ease;
}

.global-nav a:hover,
.global-nav a[aria-current="page"] {
  color: var(--blue);
}

.menu-toggle {
  display: none;
  width: 44px;
  height: 44px;
  padding: 9px;
  border: 0;
  background: transparent;
}

.menu-toggle span {
  display: block;
  width: 100%;
  height: 2px;
  margin: 6px 0;
  background: var(--navy);
  transition: transform 0.2s, opacity 0.2s;
}

.page-top-button {
  position: fixed;
  right: 28px;
  bottom: var(--page-top-bottom, 28px);
  z-index: 120;
  width: 78px;
  height: 78px;
  display: grid;
  place-items: center;
  border: 0;
  border-radius: 50%;
  color: #fff;
  background: var(--footer);
  font-family: var(--font-sans);
  font-size: 18px;
  font-weight: 500;
  line-height: 1.25;
  letter-spacing: .02em;
  text-align: center;
  cursor: pointer;
  opacity: 0;
  visibility: hidden;
  --page-top-shift: 14px;
  transform: translateY(var(--page-top-shift));
  transition:
    opacity .25s ease,
    visibility .25s ease,
    transform .25s ease;
}

.page-top-button.is-visible {
  opacity: 1;
  visibility: visible;
  --page-top-shift: 0;
}

.page-top-button:hover {
  --page-top-shift: -2px;
}

.page-top-button:focus-visible {
  outline: 3px solid rgba(23, 131, 186, .35);
  outline-offset: 4px;
}

.hero {
  min-height: 605px;
  position: relative;
  overflow: hidden;
  color: var(--navy);
  background: #f7fbff url("../images/hero-bg.png") center right / cover no-repeat;
}

.hero::before,
.hero::after {
  content: "";
  position: absolute;
  display: none;
  pointer-events: none;
}

.hero::before {
  top: 78px;
  right: -90px;
  width: 470px;
  height: 470px;
  border: 1px solid rgba(7, 29, 82, .11);
  border-radius: 50%;
  box-shadow:
    0 0 0 72px rgba(7, 29, 82, .045),
    0 0 0 144px rgba(7, 29, 82, .025);
}

.hero::after {
  top: 130px;
  right: 32px;
  width: 340px;
  height: 340px;
  opacity: .1;
  background-image: radial-gradient(circle, var(--purple) 1.2px, transparent 1.4px);
  background-size: 22px 22px;
  -webkit-mask-image: radial-gradient(circle, #000 0 48%, transparent 76%);
  mask-image: radial-gradient(circle, #000 0 48%, transparent 76%);
}

.hero .section-inner {
  position: relative;
  z-index: 1;
  padding-top: 108px;
}

.hero-copy {
  margin: 0 0 72px;
  font-family: var(--font-serif);
  font-size: 37px;
  font-weight: 600;
  line-height: 1.65;
  letter-spacing: .12em;
}

.hero h1,
.section-title {
  margin: 0;
  font-family: var(--font-serif);
  font-weight: 600;
}

.hero h1 {
  margin-bottom: 12px;
  font-size: 40px;
  line-height: 1.25;
}

.hero-text {
  max-width: 780px;
  margin: 0;
  font-weight: 500;
  line-height: 1.85;
}

.intro {
  background: var(--muted);
}

.intro .section-inner {
  padding-block: 80px 74px;
}

.intro p,
.approach-copy {
  margin: 0;
  font-weight: 500;
  letter-spacing: .015em;
}

.approach .section-inner {
  padding-block: 78px 92px;
}

.section-title {
  color: var(--navy);
  font-size: 40px;
  line-height: 1.3;
  text-align: center;
}

.approach-copy {
  margin-top: 58px;
}

.learn-more {
  display: inline-block;
  margin-top: 2px;
  color: #111;
  font-weight: 600;
  text-underline-offset: 5px;
}

.approach-visual {
  max-width: 1040px;
  margin: 68px auto 0;
  display: grid;
  grid-template-columns: 1fr 1.12fr;
  gap: 34px 48px;
  align-items: stretch;
}

.approach-image {
  display: block;
  width: 100%;
  height: auto;
  background: #f7f9fc;
}

.molecule-card,
.features-card,
.photo-card,
.mechanism-card {
  min-height: 210px;
  border: 1px solid #c9ced7;
  background: #f4f4f4;
}

.molecule-card {
  display: grid;
  place-items: center;
  border: 0;
  background: transparent;
}

.molecule {
  position: relative;
  width: 255px;
  height: 145px;
  border: 4px solid #252e7a;
  border-radius: 50% 35%;
  transform: rotate(-8deg);
  background: linear-gradient(90deg, #727ee5, #d6d9ff 45%, #616fda);
}

.molecule::before,
.molecule::after {
  content: "";
  position: absolute;
  inset: 25px -38px;
  border: 3px solid #17235f;
  border-radius: 50%;
  transform: rotate(18deg);
}

.molecule::after {
  inset: -20px 60px;
  transform: rotate(80deg);
}

.molecule-label {
  position: absolute;
  inset: 0;
  display: grid;
  place-items: center;
  color: #a32626;
  font-size: 20px;
  font-weight: 800;
  transform: rotate(8deg);
}

.features-card {
  padding: 24px 30px;
  color: var(--navy);
  font-size: 18px;
  font-weight: 600;
  line-height: 1.65;
}

.features-card ul {
  margin: 0;
  padding: 0;
  list-style: none;
}

.features-card li::before {
  content: "✓";
  margin-right: 24px;
}

.features-card strong {
  color: #d31c2a;
}

.photo-card {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 18px;
  border: 0;
  background: transparent;
}

.photo-placeholder {
  position: relative;
  min-height: 240px;
  overflow: hidden;
  border: 1px solid #7b8492;
  background: linear-gradient(145deg, #e9ded7, #a8c2bf 50%, #6b5046);
}

.photo-placeholder:nth-child(2) {
  background: linear-gradient(145deg, #d5d6ca, #6b4e3f 55%, #c7b9a1);
}

.photo-placeholder span {
  position: absolute;
  right: 8px;
  bottom: 8px;
  padding: 2px 8px;
  color: #c32222;
  background: rgba(255,255,255,.85);
  font-weight: 800;
}

.mechanism-card {
  position: relative;
  padding: 26px;
  overflow: hidden;
  border: 4px solid #27336f;
  background: linear-gradient(#f3a6a6 0 56%, #fff1c5 56%);
}

.mechanism-card::before {
  content: "Protein (hemoglobin)       Blood";
  display: block;
  color: #632124;
  font-weight: 700;
  text-align: center;
}

.mechanism-line {
  width: 72%;
  height: 75px;
  margin: 24px auto 0;
  border: 4px solid #152b5e;
  border-width: 4px 4px 0 0;
  border-radius: 50%;
  transform: rotate(8deg);
}

.page-hero {
  min-height: 160px;
  display: flex;
  align-items: center;
  color: var(--navy);
  background: #f7fbff url("../images/hero-bg.png") center right / cover no-repeat;
}

.page-title {
  margin: 0;
  font-family: var(--font-serif);
  font-size: 43px;
  font-weight: 600;
  line-height: 1.25;
  text-align: center;
}

.science-section .section-inner {
  padding-block: 76px 84px;
}

.science-section--text .section-inner {
  padding-block: 78px 92px;
}

.science-section--last .section-inner {
  padding-bottom: 116px;
}

.science-heading {
  margin: 0;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 36px;
  font-weight: 600;
  line-height: 1.45;
  text-align: center;
}

.science-copy {
  max-width: 1200px;
  margin: 42px auto 0;
  font-weight: 500;
  line-height: 1.9;
}

.science-copy p {
  margin: 0;
}

.science-copy p + p {
  margin-top: 12px;
}

.science-image {
  display: block;
  width: min(82%, 980px);
  height: auto;
  margin: 52px auto 0;
  background: #eef1f4;
}

.science-image--tall {
  width: min(82%, 860px);
}

.science-solution-sp {
  display: none;
}

.science-solution-sp img {
  display: block;
  width: 100%;
  height: auto;
}

.science-preclinical-grid {
  width: min(82%, 860px);
  margin: 52px auto 0;
  display: grid;
  grid-template-columns: minmax(0, 1fr) minmax(0, .92fr);
  gap: 18px 28px;
  align-items: center;
}

.science-preclinical-image {
  display: block;
  width: 100%;
  height: auto;
}

.science-preclinical-image--top,
.science-preclinical-image--bottom {
  grid-column: 1 / -1;
}

.science-preclinical-image--bottom {
  width: min(100%, 680px);
  margin-inline: auto;
}

.science-image-grid {
  width: min(90%, 1080px);
  margin: 52px auto 0;
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 40px;
  align-items: start;
}

.science-image-grid img {
  display: block;
  width: 100%;
  height: auto;
  background: #eef1f4;
}

.pipeline-section .section-inner {
  padding-block: 78px 116px;
}

.pipeline-heading {
  margin: 0;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 38px;
  font-weight: 600;
  line-height: 1.4;
  text-align: center;
}

.pipeline-copy {
  max-width: 1200px;
  margin: 52px auto 0;
  font-weight: 500;
  line-height: 2;
}

.pipeline-copy p {
  margin: 0;
}

.pipeline-copy p + p {
  margin-top: 16px;
}

.pipeline-image-scroll {
  width: min(84%, 980px);
  margin: 62px auto 0;
  position: relative;
}

.scroll-hint {
  display: none;
}

.scroll-arrow {
  display: none;
}

.pipeline-image {
  display: block;
  width: 100%;
  height: auto;
}

.news-archive .section-inner {
  padding-block: 78px 116px;
}

.news-index-list {
  max-width: 1080px;
  margin-inline: auto;
  border-top: 1px dotted #adb1b6;
}

.news-index-item {
  position: relative;
  display: grid;
  grid-template-columns: 190px minmax(0, 1fr);
  gap: 34px;
  padding: 20px;
  border-bottom: 1px dotted #adb1b6;
  cursor: pointer;
  transition: background-color .2s ease;
}

.news-index-item:hover {
  background: #f7f9fc;
}

.news-index-meta {
  display: flex;
  flex-direction: column;
  align-items: flex-start;
  gap: 8px;
}

.news-index-meta time {
  color: var(--navy);
  font-size: 16px;
  font-weight: 600;
  font-variant-numeric: tabular-nums;
  line-height: 1.5;
}

.news-category {
  display: inline-block;
  min-width: 74px;
  padding: 2px 10px;
  color: #2f7d5a;
  border: 1px solid #9cc5b1;
  border-radius: 2px;
  font-size: 12px;
  font-weight: 600;
  line-height: 1.5;
  text-align: center;
}

.news-index-content h2 {
  margin: 0;
  color: var(--navy);
  font-family: var(--font-sans);
  font-size: 18px;
  font-weight: 600;
  line-height: 1.55;
}

.news-index-content h2 a {
  text-decoration: none;
}

.news-index-content h2 a::after {
  content: "";
  position: absolute;
  inset: 0;
}

.news-index-content h2 a:focus-visible::after {
  outline: 2px solid var(--blue);
  outline-offset: -2px;
}

.news-index-content h2 a:hover {
  color: var(--blue);
  text-decoration: underline;
  text-underline-offset: 5px;
}

.news-index-content p {
  margin: 10px 0 0;
  color: #4d5666;
  font-size: 15px;
  line-height: 1.75;
}

.news-detail .section-inner {
  padding-block: 80px 116px;
}

.news-article {
  max-width: 880px;
  margin-inline: auto;
  padding-bottom: 72px;
}

.news-article + .news-article {
  padding-top: 72px;
  border-top: 1px dotted #adb1b6;
}

.news-article-header time {
  display: block;
  margin-bottom: 14px;
  color: #69717e;
  font-size: 15px;
  font-weight: 500;
  font-variant-numeric: tabular-nums;
}

.news-article-header h2 {
  margin: 0;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 30px;
  font-weight: 600;
  line-height: 1.5;
}

.news-article-body {
  margin-top: 42px;
  font-size: 17px;
  line-height: 2;
}

.news-article-body p {
  margin: 0;
}

.news-article-body p + p,
.news-article-body ul + p {
  margin-top: 22px;
}

.news-article-body ul {
  margin: 22px 0 0;
  padding-left: 1.5em;
}

.news-article-body li + li {
  margin-top: 5px;
}

.news-references {
  margin-top: 36px;
  padding: 24px 28px;
  background: #f7f9fc;
  border-left: 3px solid #aebbd0;
}

.news-references h3 {
  margin: 0;
  color: var(--navy);
  font-size: 16px;
  font-weight: 600;
  line-height: 1.6;
}

.news-references p {
  margin-top: 4px;
}

.news-references p + h3 {
  margin-top: 20px;
}

.news-references a,
.news-back-link {
  color: var(--blue);
  font-weight: 600;
  text-underline-offset: 4px;
}

.news-back-link {
  width: fit-content;
  margin: 8px auto 0;
  display: block;
}

.coming-soon-section {
  overflow: hidden;
  background: #fff;
}

.coming-soon-section .section-inner {
  min-height: 480px;
  display: grid;
  place-items: center;
  padding-block: 100px;
}

.coming-soon {
  margin: 0;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 36px;
  font-weight: 600;
  letter-spacing: .08em;
  line-height: 1.5;
  text-align: center;
}

.publications-section {
  overflow: hidden;
  background: #fff;
}

.publications-section .section-inner {
  max-width: 980px;
  padding-block: 72px 100px;
}

.publication-list {
  counter-reset: publication 6;
  margin: 0;
  padding-left: 0;
  color: #202a3d;
  list-style: none;
}

.publication-list li {
  counter-increment: publication -1;
  display: grid;
  grid-template-columns: 1.35em minmax(0, 1fr);
  gap: 0;
  padding: 22px 0;
  border-bottom: 1px dotted #adb1b6;
}

.publication-list li:first-child {
  padding-top: 0;
}

.publication-list li::before {
  grid-column: 1;
  content: counter(publication) ".";
  color: var(--navy);
  font-weight: 700;
  line-height: 1.45;
}

.publication-list li > * {
  grid-column: 2;
}

.publication-list p {
  margin: 0;
}

.publication-image {
  width: min(100%, 560px);
  margin: 14px auto 0;
  aspect-ratio: 16 / 9;
  display: grid;
  place-items: center;
  overflow: hidden;
  border-radius: 0;
  background-color: transparent;
  background-position: center;
  background-size: contain;
  background-repeat: no-repeat;
}

.publication-image span {
  display: none;
}

.publication-authors {
  color: var(--navy);
  letter-spacing: 0.01em;
  line-height: 1.45;
}

.publication-title {
  margin-top: 5px !important;
  color: rgb(37, 28, 167);
  font-weight: 700;
  line-height: 1.5;
}

.publication-journal {
  margin-top: 5px !important;
  color: #3d4554;
  line-height: 1.5;
}

.journal-name {
  font-style: italic;
  font-weight: 700;
}

.journal-volume {
  font-style: italic;
  font-weight: 700;
}

.publication-doi {
  margin-top: 4px !important;
  color: #556070;
  font-size: 15px;
  line-height: 1.45;
  word-break: break-word;
}

.publication-doi a {
  color: var(--blue);
  text-underline-offset: 4px;
}

.contact-section {
  overflow: hidden;
  background: #fff;
}

.contact-section .section-inner {
  min-height: 480px;
  display: grid;
  place-items: center;
  padding-block: 100px;
}

.contact-content {
  max-width: 820px;
  text-align: center;
}

.contact-content p {
  margin: 0;
  font-size: 18px;
  font-weight: 500;
  line-height: 2;
}

.contact-person {
  margin-top: 28px !important;
  color: var(--navy);
  font-weight: 600 !important;
}

.contact-email {
  display: inline-block;
  margin-top: 18px;
  color: var(--navy);
  font-size: 25px;
  font-weight: 600;
  letter-spacing: .04em;
  line-height: 1.5;
}

.contact-note {
  margin-top: 10px !important;
  color: #4f5968;
  font-size: 14px !important;
  font-weight: 400 !important;
  line-height: 1.6 !important;
}

.team-section .section-inner {
  padding-block: 78px 116px;
}

.team-section--members .section-inner {
  padding-bottom: 48px;
}

.team-section--supporters .section-inner {
  padding-top: 30px;
}

.team-section--business-supporters .section-inner {
  padding-block: 30px 104px;
}

.team-heading {
  margin: 0 0 52px;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 38px;
  font-weight: 600;
  line-height: 1.4;
  text-align: center;
}

.team-grid--members {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: clamp(18px, 2vw, 30px);
}

.team-card {
  min-width: 0;
  display: flex;
  flex-direction: column;
  border-radius: 10px;
  text-align: center;
}

.team-section--members .team-card {
  width: 100%;
  padding: 32px 22px 28px;
  border: 1px solid #e0e5eb;
  background: #fff;
  box-shadow: 0 7px 20px rgba(7, 29, 82, .07);
  cursor: pointer;
  transition: border-color .2s ease, box-shadow .2s ease, transform .2s ease;
}

.team-section--members .team-card:hover,
.team-section--members .team-card:focus-visible {
  border-color: #bdc9d8;
  box-shadow: 0 10px 26px rgba(7, 29, 82, .12);
  transform: translateY(-2px);
  outline: none;
}

.team-grid--supporters {
  display: grid;
  grid-template-columns: repeat(5, minmax(0, 1fr));
  gap: clamp(18px, 1.8vw, 30px) clamp(14px, 1.6vw, 22px);
}

.team-grid--business-supporters {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: clamp(18px, 2vw, 30px);
}

.team-section--supporters .team-card {
  padding: 22px 14px 20px;
  border: 1px solid #e3e7ec;
  background: #fff;
  box-shadow: 0 4px 13px rgba(7, 29, 82, .045);
}

.team-section--business-supporters .team-card {
  padding: 28px 18px 24px;
  border: 1px solid #e3e7ec;
  background: #fff;
  box-shadow: 0 4px 13px rgba(7, 29, 82, .045);
  cursor: default;
}

.member-trigger {
  width: 100%;
  padding: 0;
  display: flex;
  flex-direction: column;
  align-items: center;
  color: inherit;
  border: 0;
  background: transparent;
  cursor: pointer;
}

.member-photo {
  display: block;
  width: 150px;
  height: 150px;
  flex: 0 0 150px;
  margin-inline: auto;
  object-fit: cover;
  border-radius: 50%;
  border: 1px solid #e0e5eb;
  background: #edf0f3;
  transition: opacity .2s ease, transform .2s ease;
}

.team-section--supporters .member-photo {
  width: 104px;
  height: 104px;
  flex-basis: 104px;
}

.team-section--business-supporters .member-photo {
  width: 120px;
  height: 120px;
  flex-basis: 120px;
}

.team-section--members .team-card:hover .member-photo,
.team-section--members .team-card:focus-visible .member-photo {
  opacity: .88;
  transform: translateY(-3px);
}

.member-name {
  display: block;
  margin-top: 20px;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 21px;
  font-weight: 600;
  line-height: 1.45;
}

.team-section--supporters .member-name {
  margin: 14px 0 0;
  font-size: 17px;
}

.team-section--business-supporters .member-name {
  margin: 20px 0 0;
  font-size: 21px;
  line-height: 1.45;
}

.team-section--supporters .member-role,
.team-section--supporters .member-field,
.team-section--supporters .member-affiliation,
.team-section--business-supporters .member-role,
.team-section--business-supporters .member-affiliation {
  font-size: 15px;
  line-height: 1.65;
}

.member-role,
.member-field,
.member-affiliation {
  margin: 7px 0 0;
  font-size: 15px;
  line-height: 1.65;
}

.team-section--members .member-affiliation {
  margin-top: 10px;
  padding-top: 0;
}

.member-logos {
  min-height: 86px;
  margin-top: auto;
  padding-top: 12px;
  display: grid;
  grid-auto-flow: column;
  grid-auto-columns: 64px;
  justify-content: center;
  align-items: center;
  gap: 6px;
}

.member-logos img {
  display: block;
  width: 64px;
  height: 64px;
  object-fit: contain;
}

.member-logos--takayama img {
  transform: scale(.8);
}

.member-logos--text {
  display: flex;
  justify-content: center;
  align-items: center;
  color: #30394b;
  font-size: 14px;
  font-weight: 600;
  line-height: 1.5;
}

.team-section--supporters .member-affiliation {
  margin-top: 10px;
  padding-top: 0;
}

.member-role {
  color: #2f7d5a;
  font-weight: 600;
}

.member-field {
  color: #4d5666;
}

.member-affiliation {
  color: #30394b;
  margin-top: auto;
  padding-top: 14px;
}

.team-modal {
  width: min(calc(100% - 40px), 760px);
  max-height: calc(100vh - 40px);
  padding: 0;
  overflow: auto;
  color: var(--ink);
  border: 0;
  border-radius: 10px;
  box-shadow: 0 24px 70px rgba(7, 29, 82, .25);
}

.team-modal::backdrop {
  background: rgba(7, 18, 44, .6);
}

.team-modal-inner {
  position: relative;
  padding: 52px;
}

.team-modal-close {
  position: absolute;
  top: 14px;
  right: 16px;
  width: 40px;
  height: 40px;
  padding: 0;
  color: var(--navy);
  border: 0;
  background: transparent;
  font-size: 30px;
  line-height: 1;
  cursor: pointer;
}

.team-modal-layout {
  display: grid;
  grid-template-columns: 220px minmax(0, 1fr);
  gap: 38px;
  align-items: start;
}

.team-modal-photo {
  display: block;
  width: 100%;
  aspect-ratio: 1;
  object-fit: cover;
  border-radius: 50%;
  background: #edf0f3;
}

.team-modal-name {
  margin: 0 0 14px;
  color: var(--navy);
  font-family: var(--font-serif);
  font-size: 28px;
  line-height: 1.4;
}

.team-modal-meta,
.team-modal-profile {
  margin: 8px 0 0;
  line-height: 1.75;
}

.team-modal-meta[data-modal-role] {
  color: #2f7d5a;
  font-weight: 700;
}

.team-modal-profile {
  margin-top: 22px;
}

.news .section-inner {
  padding-block: 8px 100px;
}

.news .news-index-list {
  margin-top: 58px;
}

.news-list {
  max-width: 1040px;
  margin: 58px auto 0;
  padding: 0;
  list-style: none;
}

.news-list li {
  display: grid;
  grid-template-columns: 180px 26px 1fr;
  gap: 18px;
  align-items: baseline;
  margin-bottom: 14px;
  font-weight: 500;
}

.news-list .divider {
  color: #60646d;
}

.news-list a {
  text-decoration: none;
}

.news-list a:hover {
  text-decoration: underline;
}

.site-footer {
  position: relative;
  overflow: hidden;
  color: #fff;
  background: var(--footer);
}

.footer-inner {
  min-height: 320px;
  position: relative;
  z-index: 1;
  display: grid;
  grid-template-columns: minmax(0, 400px) minmax(280px, 380px);
  align-content: start;
  align-items: start;
  gap: 40px;
  justify-content: start;
  padding-block: 74px 96px;
}

.footer-brand {
  display: grid;
  grid-template-columns: 40px minmax(0, 1fr);
  column-gap: 15px;
  row-gap: 12px;
  align-items: start;
}

.footer-brand .brand {
  display: contents;
}

.footer-brand .brand-name {
  grid-column: 2;
  grid-row: 1;
  align-self: center;
  color: #fff;
  font-size: 32px;
  line-height: 1.25;
}

.footer-brand .brand-mark {
  grid-column: 1;
  grid-row: 1 / 3;
  width: 40px;
  height: auto;
  transform: translateY(5px);
}

.footer-subtitle {
  grid-column: 2;
  grid-row: 2;
  margin: 0;
  font-size: 16px;
  font-weight: 600;
  line-height: 1.75;
}

.footer-address {
  width: min(100%, 380px);
  justify-self: start;
  margin: 8px 0 0;
  font-size: 16px;
  font-weight: 500;
  line-height: 1.8;
  text-align: left;
}

.copyright {
  position: absolute;
  left: 0;
  right: 0;
  bottom: 34px;
  margin: 0;
  font-size: 13px;
  opacity: .78;
  text-align: center;
}

@media (min-width: 901px) {
  .header-main {
    gap: 42px;
  }

  .global-nav {
    position: sticky;
    top: 0;
    z-index: 100;
    padding: 0;
    box-shadow: 0 2px 8px rgba(7, 29, 82, .04);
  }

  .global-nav a {
    padding: 21px 14px;
  }
}

@media (max-width: 900px) {
  body { font-size: 16px; }
  .global-nav { padding-bottom: 10px; }
  .header-main,
  .global-nav ul,
  .section-inner,
  .footer-inner { width: min(calc(100% - 40px), var(--content)); }
  .header-main {
    min-height: 88px;
    display: grid;
    grid-template-columns: minmax(0, 1fr) auto auto;
    gap: 7px 12px;
    padding: 15px 0 6px;
  }
  .brand { gap: 15px; }
  .brand-mark { width: 30px; height: auto; }
  .brand-name { font-size: 25px; }
  .site-header .brand { min-width: 0; }
  .site-header .brand-name { display: block; font-size: clamp(18px, 2.8vw, 25px); }
  .institute {
    grid-column: 1 / -1;
    grid-row: 2;
    display: block;
    padding-left: 46px;
    font-size: 12px;
    line-height: 1.5;
  }
  .header-main .language-switch { display: none; }
  .menu-toggle { display: block; cursor: pointer; }
  .global-nav { border-top: 1px solid transparent; }
  .global-nav ul {
    width: 100%;
    max-height: 0;
    display: block;
    overflow: hidden;
    transition: max-height .3s ease;
  }
  .global-nav.is-open { border-top-color: var(--line); }
  .global-nav.is-open ul { max-height: 500px; padding-bottom: 4px; }
  .global-nav li { border: 0; border-bottom: 1px solid #eceef2; text-align: left; }
  .global-nav li:last-child { border-bottom: 0; }
  .global-nav a { padding: 14px 24px; }
  .global-nav .nav-language { display: block; }
  .global-nav .nav-language a { display: flex; align-items: center; gap: 8px; color: #2f7d5a; font-weight: 600; }
  .global-nav .nav-language a::before { width: 17px; height: 17px; }
  .global-nav .nav-language a:hover { color: #246347; }
  .menu-toggle[aria-expanded="true"] span:nth-child(1) { transform: translateY(8px) rotate(45deg); }
  .menu-toggle[aria-expanded="true"] span:nth-child(2) { opacity: 0; }
  .menu-toggle[aria-expanded="true"] span:nth-child(3) { transform: translateY(-8px) rotate(-45deg); }
  .hero { min-height: 452px; }
  .hero::before { right: -250px; }
  .hero::after { right: -115px; opacity: .08; }
  .hero .section-inner { padding-top: 58px; }
  .hero-copy { margin-bottom: 55px; font-size: clamp(25px, 6vw, 34px); }
  .hero h1, .section-title { font-size: 34px; }
  .page-title { font-size: 40px; }
  .science-section .section-inner { padding-block: 62px 70px; }
  .science-heading { font-size: 31px; }
  .science-copy { margin-top: 32px; }
  .science-image { margin-top: 40px; }
  .science-preclinical-grid { margin-top: 40px; gap: 16px 22px; }
  .science-image-grid { margin-top: 40px; gap: 24px; }
  .pipeline-section .section-inner { padding-block: 62px 86px; }
  .pipeline-heading { font-size: 32px; }
  .pipeline-copy { margin-top: 38px; line-height: 1.9; }
  .pipeline-image-scroll { margin-top: 48px; }
  .news-archive .section-inner { padding-block: 62px 86px; }
  .news-index-item { grid-template-columns: 165px minmax(0, 1fr); gap: 24px; }
  .news-detail .section-inner { padding-block: 64px 90px; }
  .news-article-header h2 { font-size: 27px; }
  .coming-soon-section .section-inner { min-height: 400px; padding-block: 80px; }
  .contact-section .section-inner { min-height: 400px; padding-block: 80px; }
  .team-section .section-inner { padding-block: 62px 86px; }
  .team-section--members .section-inner { padding-bottom: 40px; }
  .team-section--business-supporters .section-inner { padding-block: 26px 84px; }
  .team-section--supporters .section-inner { padding-top: 26px; }
  .team-heading { margin-bottom: 42px; font-size: 32px; }
  .team-grid--members {
    max-width: 720px;
    margin-inline: auto;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 34px 20px;
  }
  .team-grid--business-supporters { grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 28px 20px; }
  .team-grid--supporters { grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 28px 20px; }
  .approach-visual { grid-template-columns: 1fr; max-width: 560px; }
  .footer-inner { min-height: 320px; grid-template-columns: 1fr 1fr; gap: 60px; }
}

@media (max-width: 600px) {
  .header-main,
  .section-inner,
  .footer-inner { width: min(calc(100% - 32px), var(--content)); }
  .site-header .brand { padding-right: 48px; }
  .menu-toggle { position: absolute; top: 8px; right: 0; }
  .brand-name,
  .site-header .brand-name { font-size: 21px; }
  .hero { min-height: 389px; }
  .hero::before,
  .hero::after { display: none; }
  .hero .section-inner { padding-top: 48px; }
  .hero-copy { margin-bottom: 48px; font-size: 25px; line-height: 1.6; }
  .hero h1 { font-size: 31px; }
  .hero-text br { display: none; }
  .page-hero { min-height: 90px; }
  .page-title { font-size: 30px; }
  .science-section .section-inner,
  .science-section--text .section-inner { padding-block: 48px 58px; }
  .science-section--last .section-inner { padding-bottom: 76px; }
  .science-heading { font-size: 27px; line-height: 1.5; }
  .science-copy { margin-top: 26px; line-height: 1.85; }
  .science-image,
  .science-image--tall { width: 100%; margin-top: 32px; }
  .science-solution-image { display: none; }
  .science-solution-sp {
    width: 100%;
    margin-top: 32px;
    display: grid;
    gap: 20px;
  }
  .science-preclinical-grid { width: 100%; grid-template-columns: 1fr; margin-top: 32px; gap: 18px; }
  .science-preclinical-image--top,
  .science-preclinical-image--bottom { grid-column: auto; }
  .science-preclinical-image--bottom { width: 100%; }
  .science-image-grid { width: 100%; grid-template-columns: 1fr; margin-top: 32px; gap: 20px; }
  .pipeline-section .section-inner { padding-block: 48px 68px; }
  .pipeline-heading { font-size: 28px; }
  .pipeline-copy { margin-top: 28px; line-height: 1.85; }
  .pipeline-copy p + p { margin-top: 14px; }
  .pipeline-image-scroll {
    width: 100%;
    margin-top: 36px;
    overflow-x: auto;
    -webkit-overflow-scrolling: touch;
    padding-bottom: 8px;
  }
  .scroll-arrow {
    position: absolute;
    left: 90%;
    top: 53%;
    z-index: 2;
    width: 45px;
    height: 45px;
    margin: 0;
    display: grid;
    place-items: center;
    border-radius: 50%;
    color: #fff;
    background: rgba(88, 92, 102, .46);
    font-family: var(--font-sans);
    font-size: 34px;
    font-weight: 700;
    line-height: 1;
    pointer-events: none;
    opacity: .86;
    transform: translate(-50%, -50%);
    transition: opacity .25s ease, transform .25s ease, visibility .25s ease;
  }
  .scroll-hint {
    width: fit-content;
    margin: 0 0 10px auto;
    display: block;
    color: var(--navy);
    font-size: 12px;
    font-weight: 600;
    letter-spacing: .04em;
    opacity: .72;
    transition: opacity .25s ease, transform .25s ease, visibility .25s ease;
  }
  .pipeline-image-scroll.is-scrolled .scroll-arrow,
  .pipeline-image-scroll.is-scrolled .scroll-hint {
    opacity: 0;
    visibility: hidden;
    transform: translateX(8px);
  }
  .pipeline-image-scroll.is-scrolled .scroll-arrow {
    transform: translate(calc(-50% + 8px), -50%);
  }
  .pipeline-image {
    width: 700px;
    max-width: none;
  }
  .news-archive .section-inner { padding-block: 48px 68px; }
  .news-index-item { grid-template-columns: 1fr; gap: 12px; padding: 20px 8px; }
  .news-index-meta { flex-direction: row; align-items: center; gap: 12px; }
  .news-index-meta time { font-size: 14px; }
  .news-index-content h2 { font-size: 15px; line-height: 1.55; }
  .news-index-content p { margin-top: 8px; font-size: 14px; }
  .news-detail .section-inner { padding-block: 48px 68px; }
  .news-article { padding-bottom: 50px; }
  .news-article + .news-article { padding-top: 50px; }
  .news-article-header time { margin-bottom: 10px; font-size: 14px; }
  .news-article-header h2 { font-size: 21px; line-height: 1.5; }
  .news-article-body { margin-top: 28px; font-size: 15px; line-height: 1.9; }
  .news-references { margin-top: 28px; padding: 20px; }
  .coming-soon-section .section-inner { min-height: 320px; padding-block: 64px; }
  .coming-soon { font-size: 28px; }
  .publications-section .section-inner { padding-block: 48px 68px; }
  .publication-list { padding-left: 0; font-size: 15px; }
  .publication-list li { padding: 18px 0; }
  .publication-image { width: min(100%, 340px); aspect-ratio: 4 / 3; margin-top: 12px; }
  .publication-doi { font-size: 13px; }
  .contact-section .section-inner { min-height: 340px; padding-block: 64px; }
  .contact-content p { font-size: 15px; line-height: 1.9; }
  .contact-email { margin-top: 16px; font-size: 21px; }
  .team-section .section-inner { padding-block: 48px 68px; }
  .team-section--members .section-inner { padding-bottom: 32px; }
  .team-section--business-supporters .section-inner { padding-block: 20px 68px; }
  .team-section--supporters .section-inner { padding-top: 20px; }
  .team-heading { margin-bottom: 32px; font-size: 28px; }
  .team-grid--members,
  .team-grid--business-supporters,
  .team-grid--supporters { grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 16px 12px; }
  .team-grid--members { max-width: 100%; }
  .team-card { width: 100%; margin-inline: auto; }
  .team-section--members .team-card { padding: 22px 10px 18px; }
  .team-section--business-supporters .team-card { padding: 18px 8px 16px; }
  .team-section--supporters .team-card { padding: 18px 8px 16px; }
  .member-photo { width: 108px; height: 108px; flex-basis: 108px; }
  .team-section--business-supporters .member-photo { width: 86px; height: 86px; flex-basis: 86px; }
  .team-section--supporters .member-photo { width: 80px; height: 80px; flex-basis: 80px; }
  .member-name { margin-top: 14px; font-size: 16px; }
  .team-section--business-supporters .member-name { margin-top: 14px; font-size: 16px; }
  .team-section--supporters .member-name { font-size: 16px; }
  .member-role,
  .member-field,
  .member-affiliation { font-size: 12px; line-height: 1.55; }
  .team-section--business-supporters .member-role,
  .team-section--business-supporters .member-affiliation { font-size: 12px; line-height: 1.55; }
  .team-section--supporters .member-role,
  .team-section--supporters .member-field,
  .team-section--supporters .member-affiliation { font-size: 12px; line-height: 1.55; }
  .member-logos { min-height: 52px; padding-top: 8px; grid-auto-columns: 36px; gap: 4px; }
  .member-logos img { width: 36px; height: 36px; }
  .team-modal-inner { padding: 52px 24px 30px; }
  .team-modal-layout { grid-template-columns: 1fr; gap: 24px; }
  .team-modal-photo { width: min(100%, 190px); margin-inline: auto; }
  .team-modal-name { font-size: 24px; }
  .intro .section-inner { padding-block: 54px; }
  .approach .section-inner { padding-block: 56px 70px; }
  .section-title { font-size: 31px; }
  .approach-copy { margin-top: 38px; }
  .approach-visual { margin-top: 46px; gap: 22px; }
  .features-card { min-height: 0; padding: 20px; font-size: 15px; }
  .features-card li::before { margin-right: 10px; }
  .photo-placeholder { min-height: 170px; }
  .mechanism-card { min-height: 195px; }
  .news .section-inner { padding-bottom: 68px; }
  .news .news-index-list { margin-top: 38px; }
  .news-list { margin-top: 38px; }
  .news-list li { grid-template-columns: 1fr; gap: 0; margin-bottom: 20px; }
  .news-list .divider { display: none; }
  .news-list time { color: #596270; font-size: 14px; }
  .footer-inner { min-height: 0; grid-template-columns: 1fr; gap: 0; padding: 58px 0 28px; }
  .footer-brand { grid-template-columns: 34px minmax(0, 1fr); column-gap: 15px; row-gap: 10px; }
  .footer-brand .brand-mark { width: 34px; }
  .footer-brand .brand-name { font-size: 25px; }
  .footer-subtitle { margin: 0; font-size: 14px; }
  .footer-address { justify-self: start; margin-top: 46px; font-size: 15px; }
  .copyright { position: static; margin-top: 28px; font-size: 12px; }
  .page-top-button {
    right: 18px;
    bottom: var(--page-top-bottom, 18px);
    width: 62px;
    height: 62px;
    font-size: 14px;
  }
}